Department of Imaging Physics, Delft University of Technology

Optical diffraction/​projection tomography


Here you find an overview of the research topics in the field of optical tomography (optical diffraction/projection tomography).

Optical diffraction/projection tomography

High quality imaging is of paramount importance in a variety of application areas. Imaging performance is assessed on three major benchmarks: image resolution, amount of volume imaged, and imaging speed. In terms of these benchmarks high resolution volumetric imaging at high frame rate speed is the holy grail of imaging. My research interest are in the development and improvement of high resolution, high speed, volumetric (3D) optical imaging technology.

3D Tomography

Tomographic imaging is based on the reconstruction of the structure of an object based on projections of light emission from, or transmission through, the object. Based on the analysis of the optical imaging geometry we develop methodology to acquire optimal tomographic images, i.e., the image with the highest spatial resolution. Moreover, we develop algorithms for tomographic image reconstruction based on analytical models and iterative reconstruction techniques. 3D tomographic techniques are applied to fundamental biology and medicine in the form of zebrafish and optical biopsy imaging, respectively.

Tomographic image reconstruction of a GFP labeled zebrafish. Original reconstruction (middle) and deconvoluted reconstruction (right). Data from this publication.